Mucoadhesive nasal gel delivery system for non-sedating antihistamines
Innovative nasal gel delivery system enhances bioavailability and retention for antihistamines using GelMAP and mPEG-PCL micelles. Offers rapid, sustained relief with user-friendly application, targeting allergy treatment gaps.
Overview
The mucoadhesive nasal gel delivery system is designed to significantly improve the bioavailability and nasal retention of non-sedating antihistamines such as loratadine and fexofenadine. By utilizing GelMA nanoparticles modified with PBA (GelMAP), this system achieves enhanced mucoadhesion through reversible boronate ester complexes. The inclusion of mPEG-PCL block copolymers forms micelles that increase the loading and solubilization of hydrophobic drugs. This innovative design addresses existing treatment gaps in allergic rhinitis by ensuring rapid and sustained therapeutic outcomes.
Technical specifications
- Mucoadhesion: GelMAP facilitates strong nasal adhesion via boronate ester complexes.
- Micelle formation: mPEG-PCL copolymers enhance drug loading and solubilization.
- Shear-thinning matrix: Comprised of HA and Hypromellose, supported by Glycerin, for easy application and extended retention.
- Photo-crosslinking: Stabilizes the GelMA matrix for reliable drug delivery.
- Drug versatility: Capable of loading both hydrophobic and hydrophilic antihistamines for sustained release.
Technology readiness level
Currently at TRL 4, this technology has undergone initial development and optimization phases, including the synthesis and characterization of key components. Future plans include comprehensive in vitro efficacy and safety assessments, along with the development of a user-friendly applicator prototype.
About Texas A&M University, College Station
Texas A&M University in College Station is a comprehensive public research university and the flagship of The Texas A&M University System, combining broad academic strengths with a strong applied‑research culture. Industry collaborates on the Texas A&M‑RELLIS campus—an integrated education, research and testing environment that supports large‑scale experimentation and proving grounds—and through the Texas A&M Transportation Institute’s facilities in Bryan‑College Station. A statewide extension network connects university expertise to companies and communities across all Texas counties, enabling rapid piloting and deployment. Research is supported by competitive federal funding from agencies such as NSF, NIH, DOE, USDA and DoD, alongside state and industry sponsorship. Texas A&M Innovation provides IP management, licensing and commercialization pathways across the system.
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