Microbial oral health ingredients via biomass fermentation for dogs

Technology
Conceptual
University

Innovative biomass fermentation process to create a probiotic yeast-based ingredient for dog oral health, aiming to reduce plaque, control bad breath, and support gum health through microbiome modulation.

Overview

This cutting-edge solution involves the development of a microbial oral health ingredient for dogs, produced through biomass fermentation. The key innovation lies in utilizing a food-grade probiotic yeast to create a powder rich in postbiotics, such as β glucans and mannoproteins, which are known to modulate the oral microbiome. This ingredient aims to reduce plaque, control bad breath, and support gum health by shifting the ecology of the canine oral microbiome. The ingredient is neutral in taste and smell, stable at room temperature, and can be easily integrated into dog food or as a spray.

Technical specifications
  • Probiotic Yeast Fermentation: Cultivated under controlled conditions to produce a biomass powder enriched with yeast-derived prebiotics and fermentation metabolites.
  • Key Components: β glucans, mannoproteins, peptides, and a variety of metabolites.
  • Product Formats: Can be incorporated into dog food or delivered as a spray.
  • Scalability: Successfully piloted at 100L scale with plans to scale up to 3,000L.
  • Safety: Comprehensive safety tests completed, covering microbial quality, mycotoxin levels, and heavy metals.
Technology readiness level

The technology is currently at TRL 3, with pilot studies demonstrating reproducibility and efficiency. Future validation plans include optimizing fermentation conditions, developing prototype formats, and conducting in-vivo studies to monitor the gum microbiome and health in dogs. Field studies and regulatory documentation are planned to support product registration and market launch.


About Agency for Science, Technology and Research

ASTAR is Singapore’s national applied research agency, comprising a network of research institutes and shared facilities that drive innovation for the public and private sectors. Co-located campuses at one-north (Biopolis and Fusionopolis) link institutes with corporate R&D, startups, and investors for rapid collaboration. Industry programs provide access to advanced equipment with expert support, alongside multi‑party consortia and initiatives aligned with national priorities. The agency’s work is primarily supported through Singapore’s Research, Innovation & Enterprise programs via the National Research Foundation, with additional industry co‑funding. Commercialization is led by Accelerate, which manages IP, licensing, and venture creation.

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