HCS project to screen compounds for hair follicle biology
Hair follicle studies utilizing 2D (or 3D) cultured cell assays in 384 well plates would be an perfect match for our group to do compound screening. We have a dozen targeted small molecule libraries for use, or can utilize available libraries as available. Recent papers below speak to our capabilities.
Stossi et al. Quality Control for Single Cell Imaging Analytics Using Endocrine Disruptor-Induced Changes in Estrogen Receptor Expression. Environ Health Perspect. 2022. 130(2):27008. PMCID: PMC8846386. 2. Stossi et al. SPACe: an open-source, single-cell analysis of Cell Painting data. Nat Commun. 2024. 15(1):10170. PMCID: PMC11585637. 3. 4. Bolt et al. Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta. iScience. 2024. 27(3):109275. PMCID: PMC10926205. 4. Abbott et al. A novel ERβ HTM platform for testing endocrine disrupting chemicals. Heliyon. 2024. 10(1):e23119. PMCID: PMC10758781. 5. Szafran et al. Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures. iScience. 2022. 25(10):105200. PMCID: PMC9550643.
About Baylor College of Medicine
Baylor College of Medicine is a private, research‑intensive academic health center in Houston, embedded within the Texas Medical Center. Its co‑located clinical and research environment gives industry partners streamlined access to clinician‑scientists, diverse patient populations, and IRB‑enabled clinical studies. Shared core facilities and advanced instrumentation are professionally managed with fee‑for‑service access, while centralized clinical trials and biobanking units support regulated development. Research is primarily supported by the National Institutes of Health, with additional awards from other competitive federal agencies. A dedicated technology transfer office manages IP, licensing, startup formation, and industry‑sponsored research agreements.
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