Dual-crosslinked gummies for improved nutrient bioavailability
Introducing dual-crosslinked gummies that enhance the stability and bioavailability of micronutrients using a multilayered encapsulation strategy with micellar casein, inulin, trehalose, and robust crosslinking within a gelatin-pectin matrix.
Overview
This innovative solution presents dual-crosslinked gummies designed to significantly enhance the bioavailability and stability of micronutrients such as vitamins and minerals. By employing a multilayered encapsulation strategy, these gummies ensure improved absorption and sustained release of nutrients in the small intestine. The micronutrients are first encapsulated in a micellar casein core, followed by sequential coatings of inulin and trehalose. The structure is fortified through ionic interactions with potassium ions and covalent bonds facilitated by the enzyme transglutaminase, then embedded in a gelatin-pectin gel matrix.
Technical specifications
- Encapsulation Strategy: Micellar casein core coated with inulin and trehalose layers
- Crosslinking Mechanism: Utilization of potassium ions and transglutaminase for dual crosslinking
- Matrix Integration: Embedded within gelatin-pectin gummy matrices to enhance stability
- Environmental Protection: Provides robust protection against moisture, oxygen, temperature, and pH changes
- Release Profile: Ensures sustained release and targeted delivery in the small intestine
- Feasibility: Utilizes GRAS biopolymers with minimal impact on sensory attributes
Technology readiness level
Currently at Technology Readiness Level 4, this solution has undergone initial formulation and optimization phases, including stability testing and encapsulation characterization. The next phase involves embedding the cores into gummy matrices and conducting in vitro digestion models to validate nutrient release and shelf-life stability.
About Texas A&M University, College Station
Texas A&M University in College Station is a comprehensive public research university and the flagship of The Texas A&M University System, combining broad academic strengths with a strong applied‑research culture. Industry collaborates on the Texas A&M‑RELLIS campus—an integrated education, research and testing environment that supports large‑scale experimentation and proving grounds—and through the Texas A&M Transportation Institute’s facilities in Bryan‑College Station. A statewide extension network connects university expertise to companies and communities across all Texas counties, enabling rapid piloting and deployment. Research is supported by competitive federal funding from agencies such as NSF, NIH, DOE, USDA and DoD, alongside state and industry sponsorship. Texas A&M Innovation provides IP management, licensing and commercialization pathways across the system.
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