Biodegradable ph-responsive polyhydroxybutyrate micro/nanobeads
Innovative biodegradable micro/nanobeads use polyhydroxybutyrate and cellulose acetate phthalate for pH-responsive delivery of hydrophobic and water-soluble bioactive ingredients, ideal for personal care and cosmetics.
Overview
This innovative technology involves the development of biodegradable micro/nanobeads composed of polyhydroxybutyrate (PHB) and cellulose acetate phthalate (CAP). These materials create a pH-responsive matrix capable of delivering hydrophobic and water-soluble bioactive compounds. This makes them particularly suitable for applications in personal care and cosmetics, providing a sustainable and effective method for active ingredient delivery.
Technical specifications
The micro/nanobeads are formulated using a specialized protocol to load compounds like astaxanthin and niacinamide into the biodegradable PHB/CAP matrix. The beads exhibit pH-responsiveness, which allows for controlled release of the active ingredients based on environmental pH changes. Cytotoxicity assays using PSVK1 and EpiSkin® cell lines have demonstrated the safety of these microbeads, which have also passed clinical safety evaluations for skin irritation and sensitization.
Key features:
- Biodegradable and environmentally friendly
- pH-responsive release mechanism
- Suitable for hydrophobic and water-soluble compounds
- Proven non-toxic and safe in clinical trials
Technology readiness level
This technology is currently at TRL 5, indicating that it has been validated in a relevant environment. Further development and partnering are sought to advance the technology for commercial applications, with a focus on loading specific hydrophobic compounds as requested by partners.
About Chulalongkorn University
Chulalongkorn University is a comprehensive public research university in Bangkok, serving a large student body and advancing research from discovery through translation. Its campus anchors an urban innovation district where companies engage through co‑located labs, prototyping facilities, and startup incubation. The university’s integration with a major teaching hospital enables clinical studies and translational collaboration, while co‑op and executive programs connect corporate partners to talent. Research is supported by Thailand’s competitive national funding agencies and international sponsors. A dedicated technology transfer office manages IP, licensing, and startup formation, with streamlined contracting for industry‑sponsored work.
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