Toll-like receptor signaling in mitochondrial dysfunction for neurodegenerative disease treatment
Exploring the role of toll-like receptors in mitochondrial dysfunction and neuroinflammation to identify new molecular targets for treating neurodegenerative diseases like Parkinson's.
Overview
This research investigates the role of toll-like receptor (TLR) signaling pathways in mitochondrial dysfunction and neuroinflammation, particularly focusing on their impact on neurodegenerative diseases such as Parkinson's Disease (PD). By studying the crosstalk between TLRs and mitochondria, this research aims to uncover new molecular targets for therapeutic intervention, potentially leading to novel treatments for neurodegenerative disorders.
Technical specifications
- Toll-like Receptor 4 (TLR4): Key focus on its role in PD pathogenesis, with studies conducted in vitro, in vivo, and on post-mortem brain samples.
- Mitochondrial Dysfunction: Investigated as a precursor to neuroinflammation and its effect on alpha-synuclein aggregation.
- Research Methods: Utilization of TLR4-deficient mice models to study dopamine loss resistance and neuron survival in PD.
- Future Work: Development of in vitro and in vivo models, with a focus on mitochondrial metabolic activity and alpha-synuclein interaction in PD samples.
Technology readiness level
The research is currently at Technology Readiness Level 3, indicating experimental proof of concept has been achieved through rigorous in vitro and in vivo studies. Further validation and development are planned to advance the research towards clinical application.
About University of Perugia
The University of Perugia is a comprehensive public research university serving the Umbria region through multiple campuses and a broad portfolio of academic and clinical programs. Companies connect through co-located laboratories and shared-use core facilities that provide testing and prototyping, alongside contract research and joint development pathways. Integration with the university hospital enables clinical translation, while internship and thesis-placement programs give firms access to talent year round. Research activity is supported by competitive European funding and national ministries, complemented by regional programs and industry-sponsored projects. A dedicated technology transfer office manages IP protection, licensing, spinouts, and collaboration agreements.
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