Tailored amorphous multiparous materials for dental health

Overview

Tailored amorphous multiparous (TAMP) materials represent a groundbreaking advancement in dental health, specifically targeting dentin regeneration and hypersensitivity reduction. These materials are bioactive silicate glasses with carefully designed interconnected nanopores (~10 nm) and macropores (100s of microns). The nanopores enhance protein adsorption and cell response, promoting cell attachment, proliferation, and differentiation critical for dentin regeneration. Larger macropores facilitate cell migration and nutrient transport, essential for effective dental treatments. TAMP materials have demonstrated significant potential in occluding dentine tubules, thereby controlling hypersensitivity.

Technical specifications

• Bioactive Glass Composition: Utilizes calcium silicate for effective pulp capping and dentin bridge formation.
• Pore Structure: Features interconnected nanopores (~10 nm) for superior cell interaction and macropores for enhanced nutrient transport.
• Clinical Evidence: Shown to preserve alveolar bone height and promote active bone remodeling in clinical trials.
• Application Method: Applied as a slurry to dentine, reacting within seconds to provide deep occlusion and hypersensitivity control.
• Customization Potential: Future enhancements may include fluorine and potassium for expanded dental applications.

Technology readiness level

The TAMP material is currently at TRL 5, indicating validation in relevant environments. Ongoing partnerships aim to translate this technology into consumer dental care products, ensuring it meets practical application standards and regulatory requirements.