Stress-lowering botanical compounds for enzyme inhibition
Explore botanical compounds that potentially lower stress by inhibiting the enzyme 11B-hydroxysteroid dehydrogenase. Using advanced metabolomics and protein docking techniques, this research identifies and tests promising plant-based metabolites for effective stress reduction.
Overview
The project focuses on identifying and testing botanical compounds that have the potential to lower stress through the inhibition of the enzyme 11B-hydroxysteroid dehydrogenase. Leveraging advanced techniques in metabolomics, protein docking, and molecular dynamics, the research aims to discover plant-based metabolites that can serve as effective stress-relief agents. This innovative approach combines traditional ethnobotanical knowledge with cutting-edge scientific methods to validate the efficacy of these botanicals.
Technical specifications
- Metabolomics: Identification of major metabolites in plant extracts using advanced analytical techniques.
- Protein docking: Screening of metabolites through computer models to predict their interaction with the enzyme.
- Molecular dynamics: Cross-verification of docking results to ensure stability and effectiveness of the interaction.
- In vitro assays: Validation of the most promising inhibitors by determining IC50, Ki values, and mode of inhibition using Lineweaver Burk graphs.
Technology readiness level
This research is currently at Technology Readiness Level 4, indicating that the basic components have been validated in a laboratory environment. Further funding is sought to support PhD or post-doc students in advancing this work over a three-year period.
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