Stabilized hydroxyl-radical activated water sanitizer for surface decontamination

Technology
Conceptual
University

A novel liquid surface sanitizer based on stabilized hydroxyl-radical activated water that provides broad-spectrum antimicrobial activity without toxic residues. The technology uses a Fenton-like reaction with hydrogen peroxide, UV-C, and a ferric catalyst to produce hydroxyl radicals that can be stored and applied on demand for food and non-food surface disinfection.

Overview

This solution is a stabilized hydroxyl-radical activated water sanitizer designed for decontaminating food and non-food surfaces. Unlike conventional chemical sanitizers, it delivers broad-spectrum antimicrobial performance while remaining non-toxic and leaving no residues on treated surfaces. The technology adapts principles from a gas-phase hydroxyl radical process into a practical liquid format, enabling simple generation, storage, and on-demand application. The sanitizer is intended for use across food processing environments, healthcare settings, and other industries where effective surface disinfection without chemical contamination is critical.

Technical specifications

Core technology:

  • Based on a Fenton-like reaction in which hydrogen peroxide is degraded by UV-C in the presence of a ferric catalyst
  • Unlike traditional Fenton chemistry, the reaction is initiated during generation rather than requiring all reactants to be present at the point of use
  • Produces hydroxyl radicals that have been confirmed using methylene blue assays and demonstrated through inactivation of E. coli in both suspension and on surfaces
  • Uses low concentrations of reactants, making it simple and cost-effective to produce
  • Designed to retain antimicrobial activity for up to 12 months when stored in light-protected containers

Key advantages:

  • Broad antimicrobial spectrum against bacteria, viruses, and moulds
  • Non-toxic and residue-free application
  • Compatible with food-contact and non-food surfaces
  • Stable liquid format enables easy storage, distribution, and deployment
Technology readiness level

The technology has reached proof-of-principle status. The hydroxyl-radical activated water has been generated, stored, and successfully applied to disinfect surfaces, with antimicrobial activity validated through E. coli inactivation studies. The next phase of research will focus on verifying performance against a broader range of microbes including viruses, bacteria, and moulds across different surface types. Further work will include optimization studies, residue and surface alteration assessments, skin compatibility testing, shelf-life evaluation under varied conditions, and preliminary scale-up investigations.


About University of Guelph

The University of Guelph is a comprehensive, mid-sized public research university in Guelph, Ontario. Industry partners engage through an on-campus research park and the Ontario Veterinary College’s teaching hospitals, which enable product evaluation and clinical translation. The university’s Arboretum and the nearby Agriculture and Agri-Food Canada Guelph Research and Development Centre offer living laboratories and federal linkages that support collaborative R&D. Research is backed by competitive federal funding and strong provincial support via the Ontario Agri‑Food Innovation Alliance. The Research Innovation Office serves as the university’s technology transfer and industry liaison hub, supporting IP, licensing, and co‑funded partnerships.

Sign up to access the full partnering listing.
View the details of this partnering listing and connect directly with the teams behind promising technologies.
Halo home
Partner smarter. Move faster.
Get new partnering requests
delivered to your inbox.