Quantifying oligomerization of organo-trialkoxysilanes with SAXS and NMR
A novel approach combining Small angle X-ray Scattering (SAXS) and 29Si-NMR spectroscopy to monitor and quantify the oligomerization and hydrolysis of organo-trialkoxysilanes, providing comprehensive insights into reaction dynamics and structural changes.
Overview
This innovative solution provides a comprehensive approach to studying the oligomerization of organo-trialkoxysilanes. By integrating Small angle X-ray Scattering (SAXS) with solution-state 29Si-NMR spectroscopy, researchers can monitor both the initial hydrolysis stages and the subsequent growth of oligomers. This dual-method approach offers a complete view of the reaction dynamics, from early monomer formation to larger oligomer structures, thereby enabling precise control and characterization of these processes.
Technical specifications
- 29Si-NMR: Effective for characterizing initial stages of oligomerization, identifying monomer peaks, and tracking early growth.
- SAXS: Provides crucial insights into the size, shape, and structural changes of larger oligomers, especially as cluster sizes increase and NMR effectiveness diminishes.
- Calibration and Validation: Includes a phased approach to develop calibration curves and validate the method with controlled experiments and blind sample testing.
Technology readiness level
This technology is at TRL 4, indicating that it has been validated in a laboratory setting with plans for further calibration and validation phases to ensure readiness for industrial application.
About Northwestern University
Northwestern University is a comprehensive private research university with campuses in Evanston and downtown Chicago and a collaborative, cross‑disciplinary culture. Integration with a major hospital system enables clinical research, diverse patient access, and rapid translation from bench to bedside. Shared research cores, prototyping facilities, a campus incubator, and dedicated corporate engagement teams make it straightforward to scope projects, structure agreements, and place talent. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, and DoD, complemented by foundation and industry partnerships. A dedicated technology transfer office advances IP strategy, licensing, and startup formation.
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