Protein-based encapsulation for probiotic protection in low ph environments

Technology
In development
Company

Nucaps offers a protein-based encapsulation technology designed to protect probiotics from harsh gastric conditions, ensuring their viability in low pH beverages. This solution enhances probiotic delivery by releasing them in the intestinal area, supporting microbiota health.

Overview

Nucaps Nanotechnology presents an innovative protein-based encapsulation technology specifically designed to enhance the stability and viability of probiotics in low pH environments, such as acidic beverages. By forming a protective barrier, this encapsulation method ensures probiotics survive the harsh gastric conditions, allowing them to reach the intestinal area where they can confer health benefits.

Technical specifications
  • Encapsulation Technology: Uses micro- and nanoencapsulation techniques to shield probiotics from gastric pH levels ranging from 1.2 to 3.4.
  • Controlled Release: The encapsulated probiotics are released in the intestinal area through pH-triggered diffusion and erosion mechanisms.
  • Applications: Ideal for use in low pH beverages and dairy products like yogurt, where maintaining probiotic viability is crucial.
  • Proven Performance: Successfully scaled up to Technology Readiness Level 6-7, demonstrating efficacy in dairy applications.
Technology readiness level

This encapsulation technology is at Technology Readiness Level 6, indicating that it has been validated in relevant environments and is in the process of being scaled up for broader industrial application.


About NUCAPS Nanotechnology

NUCAPS Nanotechnology is a Spanish biotechnology company that specializes in a proprietary protein-based microencapsulation technology. Founded in 2017, the company designs and produces functional ingredients by encapsulating bioactives and probiotics within microscopic, food-grade protein matrices. This technology acts as a biovector, protecting sensitive ingredients from degradation while enabling controlled release, targeted delivery, and significantly enhanced bioavailability—up to 30 times higher than conventional methods. By using natural proteins such as casein, zein, or soy, the company offers a sustainable, clean-label solution that is free from synthetic polymers, fats, or additives, and is industrially scalable for various production needs.

The company operates as a B2B partner for manufacturers across the food, beverage, nutraceutical, cosmetic, and pharmaceutical industries. Its solutions address critical industry challenges, such as improving the stability and shelf life of ingredients, masking unpleasant odors and flavors, and reducing production costs. By facilitating the oral delivery of nutrients and microorganisms, NUCAPS aims to create a tangible impact on human health. With a strong focus on R&D, the company has secured multiple international patents and is recognized for its innovation in functional ingredients, supporting global nutritional objectives through science-driven, scalable technology.

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