Peg-assist encapsulation platform for enhanced scent release
The PEG-assist encapsulation platform uses a solvent-free PEG-b-PLA micelle/nanoencapsulation method to enhance and prolong scent release in topical products. It allows for high fragrance oil loading and gradual release, suitable for cough suppressants and analgesics.
Overview
The PEG-assist encapsulation platform is designed to enhance and prolong scent release in topical products, such as cough suppressants and analgesics. Utilizing a solvent-free PEG-b-PLA micelle/nanoencapsulation approach, this technology dissolves hydrophobic fragrance components and biodegradable polymers in a controlled manner, forming nanodomains that entrap fragrance oils for gradual release. This method supports high fragrance oil loading of over 10%, optimizing scent intensity and duration.
Technical specifications
Key features:
- Solvent-free encapsulation utilizing PEG as a processing medium
- High encapsulation efficiency with uniform particle size
- Freeze-drying compatibility for stability and scalability
- Adjustable viscosity via PEG molecular weight and content
- Applicable to various product forms including creams, sprays, and ointments
Technology readiness level
Currently at TRL 4, the PEG-assist platform has been demonstrated at the lab scale with plans for further validation phases. These will include incorporating fragrance-loaded carriers into product-relevant prototypes, assessing their physical stability, scent retention, and performance under accelerated conditions.
About East Tennessee State University
East Tennessee State University conducts research across health sciences, public health, clinical and translational science, addiction science, and community‑engaged social and behavioral studies, alongside strong programs in education, computing, and the arts and sciences. Notable units include the Quillen College of Medicine, the Bill Gatton College of Pharmacy, the College of Nursing, the College of Public Health, and the Center for Appalachian Studies and Services, as well as the Addiction Science Center and ETSU Health. The ETSU Research Corporation and the Innovation Lab support technology transfer, entrepreneurship, and regional industry collaboration. Research funding commonly comes from federal agencies such as the NIH, HRSA, CDC, and NSF, in addition to state and regional partners. Applied outcomes are focused on rural and telehealth delivery models, substance use disorder prevention and treatment, population health analytics, and community and workforce development in the Appalachian region.
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