Integrative dnam-rna profiling for hair and scalp aging analysis
An advanced integrative epigenetic-transcriptomic profiling method designed to evaluate aging and longevity in hair and scalp by assessing DNA methylation and RNA expression changes, providing insights into the molecular basis of aging.
Overview
This innovative solution presents an integrative approach to studying hair and scalp aging through the combined analysis of DNA methylation (DNAm) and RNA profiling. By utilizing multi-omic data, this method enables a comprehensive understanding of the molecular changes associated with aging, offering potential applications in dermatology and personalized medicine.
Technical specifications
Key features:
- Integrates high-resolution epigenetic and transcriptomic data for a holistic analysis
- Identifies genomic regions with age-dependent changes in both DNA methylation and RNA expression
- Provides insights into the molecular mechanisms of aging at the epigenomic and transcriptomic levels
- Applicable to hair and scalp tissues, expanding aging studies beyond traditional organs
Technology readiness level
The technology is currently at TRL 4, indicating that it has been validated in a laboratory environment. Further validation and development are underway to advance its readiness for broader applications.
About Harvard University
Harvard University is a comprehensive private research university in Cambridge and Boston, recognized for intensive, cross-disciplinary research and education. Industry engages through an integrated innovation ecosystem with shared core facilities, corporate-sponsored research, and incubator space in Allston. Affiliated teaching hospitals in the Longwood Medical Area enable clinical collaboration and translation, while proximity to Kendall Square places partners in a dense R&D corridor. Research is supported by major federal agencies such as the NIH, NSF, DOE and DARPA, as well as philanthropic and corporate sponsors. A dedicated technology transfer office manages IP, licensing, and startup formation and streamlines agreements for corporate collaborations.
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