Integrated tangential flow filtration and adsorption for purifying organic acids
An innovative process integrating membrane filtration and resin adsorption to efficiently purify and concentrate organic acids from fermentation broths. This method enhances recovery, reduces waste, and is compatible with industrial fermentation processes.
Overview
The proposed solution is an integrated process combining membrane filtration with resin-based adsorption to purify organic acids from fermentation broths. This method effectively concentrates organic acids, reduces impurities, and minimizes waste, making it ideal for industrial applications. By integrating tangential flow filtration with adsorptive recovery, the process improves acid recovery rates while reducing solvent and salt usage, aligning with sustainable industrial practices.
Technical specifications
Key features:
- Membrane Filtration: Utilizes a sequential process starting with microfiltration to eliminate debris, followed by ultrafiltration and nanofiltration to concentrate acids and reduce broth volume.
- Tangential Flow Filtration: Offers advantages such as reduced concentration polarization and minimized membrane fouling.
- Resin Adsorption: Employs anion-exchange resins for selective adsorption of acids, with easy desorption and resin regeneration using dilute alkali.
- Process Optimization: Statistical design of experiment is used to maximize adsorption and optimize desorption solvents for maximum acid recovery.
Technology readiness level
Currently at TRL 4, this technology has been validated in a lab environment and is now poised for further development and optimization to reach industrial readiness.
About Berkeley Lab
Berkeley Lab is a multi‑program U.S. Department of Energy national laboratory in Berkeley, operated by the University of California. Industry engages through open scientific user facilities, national high‑performance computing, co‑located nanoscience and materials characterization labs, and testbeds, with options for nonproprietary and, where permitted, proprietary work. Proximity to UC Berkeley and the Bay Area innovation ecosystem enables joint appointments, sponsored research, and talent pipelines via CRADAs and Strategic Partnership Projects. Research is funded primarily by the DOE Office of Science, with additional competitive support from other federal agencies and industry. A dedicated technology transfer office manages IP, licensing, and collaboration agreements.
Inquire about this partnering listing
Industry applications
delivered to your inbox.