Hydrophobic cellulose microgels for controlled release in aqueous environments
Biodegradable, hydrophobic cellulose microgels designed for controlled release of active ingredients in water. These microparticles offer adjustable loading and release rates, suitable for various industries, and maintain stability for up to two years.
Overview
Hydrophobic cellulose microgels represent an innovative solution for the controlled release of active ingredients (AIs) in aqueous environments. By modifying cellulose copolymers, these biodegradable microparticles are capable of sequestering hydrophobic AIs within core-shell structures. The microgels can achieve high AI concentrations exceeding 10 wt% and maintain stability in water for up to two years, making them ideal for a range of applications in pharmaceuticals, cosmetics, and other industries requiring sustained release systems.
Technical specifications
- Particle size: 5-15 μm, adjustable through polymer hydrophobicity
- Release control: Modulated by LCST, particle size, crosslinking degree, and shell materials like alginate or chitosan
- Synthesis process: Involves aqueous chemistry with phosphate-ester crosslinking, creating temperature- and pH-responsive microparticles
- AI sequestration: Achieves up to 90% AI sequestration, with high stability in water
- Production cost: Estimated at 20-25 USD/kg
Technology readiness level
This technology is currently at TRL 4, indicating that it has been validated in a laboratory setting. Future validation tasks include optimizing microparticle synthesis and AI sequestration, as well as characterizing dispersions through laser diffraction, calorimetry, and rheology.
About Clarkson University
Clarkson University is a private, national research university with a STEM-oriented character and a multi-campus footprint anchored in Potsdam, New York. Companies engage through a state-designated Center for Advanced Technology in advanced materials that supports industry collaboration and access to applied expertise. A Capital Region campus and a Hudson Valley research site extend reach into New York’s technology and manufacturing corridors, while co-op and internship pathways align talent with corporate R&D needs. Research is backed by competitive federal funding from major U.S. agencies such as the National Science Foundation and National Institutes of Health. A dedicated technology transfer office and the Shipley Center for Innovation provide IP support, incubation, and startup acceleration.
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