Hollow glucan microspheres for moisture-activated active release in oral health

Overview

The hollow glucan microspheres developed by GlucaDel represent a cutting-edge technology for oral health applications. These glucan particles, derived from Baker's Yeast, are designed to encapsulate and release active ingredients in response to moisture. This technology leverages the unique properties of beta-1,3-glucan to provide immunomodulatory and anti-inflammatory effects, making it highly suitable for oral care products. By binding to mucosal tissue surfaces and penetrating periodontal pockets, these microspheres enhance the bioavailability of active substances, offering significant advantages over traditional formulations.

Technical specifications

• Composition: Hollow cell wall ghosts from Baker's Yeast extract waste stream, primarily composed of beta-1,3-glucan.
• Particle Size: 3-4 microns.
• Applications: Encapsulation of a wide range of actives including small molecules, biologics, monoclonal antibodies, enzymes, substrates, and antimicrobial spice oils.
• Formats: Versatile formulation options including sprays, gels, dry strips, and granules.
• Functionality: Moisture-activated encapsulation and sustained release, targeted mucosal binding, and phagocyte receptor uptake.

Technology readiness level

This technology is currently at TRL 5, having been validated at pilot scale for agricultural applications and is in preclinical testing for oral health applications. GlucaDel is actively seeking partnerships for co-development, licensing, and sponsored research to advance this promising technology to the next stages of development.