High-throughput skin assay using optical coherence tomography
This innovative platform uses optical coherence tomography (OCT) for high-resolution, in vivo skin analysis without sample preparation. It enables real-time observation of biochemical treatment effects, promising breakthroughs in dermatological research and product development.
Overview
The proposed solution leverages optical coherence tomography (OCT) technology to facilitate high-throughput analysis of skin tissues. By scanning depths of 100-1000 microns, this platform can assess the structural and biochemical states of skin from the epidermis to the hypodermis, enabling real-time observation of the effects of biochemical treatments. This technology is particularly useful for visualizing structural changes caused by agents like retinoic acid and salicylic acid, providing critical insights into dermatological conditions and treatments.
Technical specifications
- OCT Technology: Utilizes a wavelength of 1050 nm, making water signals transparent and allowing unobstructed imaging of skin tissue.
- Depth of Analysis: Capable of scanning skin layers from 100 to 1000 microns, covering epidermis to hypodermis.
- Applications: Suitable for in situ observation of biochemical treatment effects, combining chemical spectroscopy with imaging to identify inflammation or allergic reactions.
- Compatibility: Integrates with existing dermatological assays for a comprehensive multi-layered skin analysis.
Technology readiness level
This technology is at TRL 5, indicating that it has been validated in relevant environments and is ready for further experimental trials. With additional funding and research, including the potential involvement of trained graduate students, the technology can advance towards commercialization within 6-9 months.
About Arizona State University
Arizona State University is a comprehensive public research university with a multi-campus presence across the Phoenix metropolitan area and a scale that supports interdisciplinary, use-inspired discovery. Industry partners access co-located laboratories, a research and technology park, and innovation centers that house corporate teams with faculty to speed prototyping and validation. A formal alliance with a major hospital system and proximity to a fast-growing manufacturing corridor enable clinical translation and pilot-scale testbeds, while applied student engagements create dependable talent pipelines. Research is backed by competitive federal funding from agencies such as NSF, NIH, DOE, DOD, and NASA. A dedicated technology transfer office supports IP, licensing, and startup formation.
delivered to your inbox.