Herbal extracts for modulation of feeding behavior

Overview

This research explores the potential of herbal extracts to modulate feeding behavior through interactions between peripheral hormones and hypothalamic neuromodulators. The focus is on altering the communication between the hypothalamus and peripheral tissues, particularly the gastrointestinal system, to influence appetite and satiety signals in vertebrates. The extracts under study, including those from Vitis vinifera and industrial hemp, have demonstrated potential anti-obesity effects.

Technical specifications

The study aims to investigate the role of herbal extracts in regulating food intake through the evaluation of GLP-1 signaling and the activity of hypothalamic neuron neuropeptides. Key neuropeptides include orexigenic NPY, AgRP, and orexin A, as well as anorexigenic CART, POMC, CRH, and BDNF. Additionally, the research examines the effects on the release and turnover of biogenic amines such as dopamine, norepinephrine, and serotonin, which are crucial in appetite regulation.

The research plan is structured into several work packages (WPs), including phytochemical characterization, in vitro studies on biological properties, biocompatibility, and gene expression assessment on gut and hypothalamic cells.

Technology readiness level

Currently, the technology readiness level is at 3, indicating that active research and development are ongoing. The research is in the experimental proof-of-concept stage, with several in vitro studies planned to further validate the efficacy and safety of the herbal extracts.