Encapsulation technology for probiotic stability in low ph beverages

Technology
In development
Company

Innovative encapsulation technology using coacervation with high bloom gelatin enhances the stability and viability of probiotics in acidic environments. Ideal for low pH beverages, this solution ensures probiotics reach the intestine effectively.

Overview

This advanced encapsulation technology utilizes coacervation with food-grade high bloom gelatin to enhance the stability and viability of probiotics in low pH beverage applications. The encapsulation process involves forming a gel through cooling and adjusting the pH, followed by cross-linking with transglutaminase to provide double-layer protection. This method ensures that probiotics are protected in the acidic stomach environment and are released in the higher pH conditions of the intestine, thereby maximizing their efficacy.

Technical specifications

Key features:

  • Encapsulation method: Coacervation using high bloom gelatin provides double-layer protection.
  • Storage stability: Encapsulated probiotics remain stable as a powder during storage.
  • Release mechanism: Gelatin capsules dissolve in intestinal conditions for targeted release.
  • Viability enhancement: Prebiotics within the capsule improve probiotic viability and stability.
  • Tested efficacy: In vitro tests show enhanced performance over non-encapsulated probiotics.
Technology readiness level

This encapsulation technology is currently at Technology Readiness Level 4, indicating that it has been validated in a laboratory environment. Further development and validation steps are planned to optimize the encapsulation formulas and assess them under real-world conditions.


About Blue California

Blue California is a vertically integrated, science-based manufacturer that designs and produces clean, sustainable, and natural ingredients. The company utilizes proprietary precision fermentation and bioconversion processes to create high-quality botanical extracts and specialty ingredients. Its operations span three main divisions: Specialty Ingredients, which focuses on nutritional components; FineCap, a platform for novel microencapsulation delivery systems; and Sensegen, which provides sustainable flavor and fragrance solutions. By leveraging advanced biotechnology, Blue California develops green production methods that ensure materials are suitable for global commercialization across multiple regulated industries.

The company serves as a collaborative partner for businesses in the food, beverage, dietary supplement, personal care, and cosmetic sectors, focusing on healthy aging and wellness solutions. Blue California distinguishes itself through a strong commitment to rigorous clinical research, sponsoring studies to validate the efficacy and safety of its proprietary ingredients, such as its flagship branded antioxidant, ErgoActive ergothioneine. This research-driven approach allows partners to build products with scientifically supported claims, helping them address evolving consumer demands for longevity, cognitive support, and functional nutrition. Their expertise in regulatory compliance and innovation assists customers in navigating complex markets while maintaining clean and sustainable supply chains.

Sign up to access the full partnering listing.
View the details of this partnering listing and connect directly with the teams behind promising technologies.
Halo home
Partner smarter. Move faster.
Get new partnering requests
delivered to your inbox.