Encapsulation and stability modeling for probiotic viability in gummy supplements
An innovative hybrid computational-experimental framework to enhance probiotic viability in gummy supplements through thermophysical modeling and formulation screening. Targets improved stability and minimal sensory impact.
Overview
Enhancing the viability of probiotics in gummy supplements is critical due to their exposure to high thermal and oxidative stress during manufacturing. This solution offers a hybrid computational-experimental framework that integrates thermophysical modeling with formulation screening. The objective is to improve probiotic survival rates in gelatin and pectin gummy matrices by identifying encapsulation systems and excipients that are thermally resilient and have minimal organoleptic impact.
Technical specifications
The framework includes:
- Thermophysical modeling: Simulations to predict probiotic degradation under typical gummy manufacturing conditions such as high temperatures (>80°C) and specific water activity levels (a_w ~0.6–0.7).
- Formulation screening: Identifying encapsulation systems and excipients that are compatible with gummy matrices and have minimal impact on taste and texture.
- GRAS-path compatible protectants: Ensuring that all selected ingredients are Generally Recognized As Safe (GRAS) and sensory-neutral.
- Experimental validation: Collaboration with a contract research partner for laboratory validation of formulations, focusing on viability during production and shelf-life.
Technology readiness level
Currently, the project is at Technology Readiness Level 3. This involves active research and development aimed at demonstrating the feasibility of the framework in a laboratory setting, with plans for future validation phases that include optimization and strain-specific calibration.
About Re-Du Company
RE-DU is a recycling technology company that has developed a patented process for the chemical deconstruction of mixed plastic waste. By breaking down diverse plastic types—such as PET, PC, PU, and PA—into monomers, the company enables the transformation of previously difficult-to-recycle materials into commercially valuable chemical products. This technology eliminates the need for costly sorting of mixed waste streams and offers an efficient, cost-effective alternative to traditional plastic management systems, which often rely on outdated processes that fail to address the majority of global plastic waste.
By providing a scalable solution for chemical recycling, RE-DU aims to reduce reliance on fossil fuels and minimize the environmental impact of plastic pollution in landfills. The company serves as a partner for industries seeking sustainable chemical feedstocks and is contributing to the development of a circular economy. Supported by initiatives like the Innovation Crossroads Award and research collaboration with Oak Ridge National Laboratory, RE-DU is positioned to help transition toward a net-zero carbon society by proving that mixed plastic waste can be successfully converted into high-quality, reusable resources.
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