Electrostatic spray drying-enabled multi-active nutraceutical platform
A novel beauty-from-within platform using electrostatic spray drying (ESD) to generate microparticles containing longevity actives like urolithin A and nicotinamide riboside. ESD enhances stability and bioavailability by controlling particle size and porosity, making it suitable for sachet, capsule, or beverage formats.
Overview
The electrostatic spray drying-enabled multi-active nutraceutical platform is an innovative solution for creating beauty-from-within products. This platform utilizes electrostatic spray drying (ESD) to produce engineered microparticles that contain longevity actives, such as urolithin A, spermidine, nicotinamide riboside (NR), and precision-fermented vegan collagen peptides. By operating at low temperatures under nitrogen, ESD protects these sensitive compounds while allowing precise control over particle size, porosity, and surface characteristics. This results in improved dispersibility and oral bioavailability, targeting aging hallmarks like mitochondrial dysfunction and extracellular matrix decline to support skin, hair, and nail health.
Technical specifications
Key features:
- Electrostatic Spray Drying (ESD): Operates at low temperature under nitrogen to prevent degradation of sensitive actives.
- Particle Engineering: Enables precise control over size, porosity, and surface architecture for enhanced dispersion and bioavailability.
- Multi-Active Co-Encapsulation: Combines urolithin A, nicotinamide riboside, spermidine, and postbiotic extracts in a single delivery system.
- Scalable and Solvent-Efficient: Compatible with food-grade inputs and suitable for GRAS-aligned nutraceutical manufacturing.
Technology readiness level
This platform is currently at Technology Readiness Level 3, indicating that it is in the experimental proof-of-concept stage. Future validation plans include optimizing ESD parameters, characterizing powders, and evaluating bioaccessibility and biological relevance in cell models. The goal is to ensure scalability, GMP compatibility, and prototype development for commercial applications.
About Catholic University of Leuven (KU Leuven)
KU Leuven is a large comprehensive public research university in Leuven, Belgium, anchored by a major academic medical center and a broad multidisciplinary profile. Industry engages through co-located facilities and shared labs, including access to advanced cleanrooms and prototyping via imec’s Leuven campus. Integration with UZ Leuven supports clinical partnerships and data-rich trials, while research and technology parks around the city connect companies with faculty and student talent. Research is backed by competitive European and Belgian funding, including the European Commission and the Research Foundation – Flanders (FWO). KU Leuven Research & Development manages IP, licensing, and spin-off formation, offering standardized agreements and dedicated partnership managers.
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