Dendritic particles for enhanced drug delivery in bladder cancer treatment
Innovative dendritic particles made of biodegradable materials for improved drug retention in bladder cancer treatments with gecko-like adhesion properties, enabling sustained drug release.
Overview
The presented technology involves the development of soft dendritic particles (SDPs) designed to enhance drug delivery in the treatment of bladder cancer. These particles are inspired by the adhesion mechanisms found in gecko feet, utilizing van der Waals forces for robust adhesion to soft and slippery surfaces such as epithelial tissues. The SDPs are composed of poly(lactic-co-glycolic acid) with a chitosan coating, providing a high surface-area-to-volume ratio crucial for effective drug retention and sustained release.
Technical specifications
The SDPs are manufactured through a novel fluid flow templating method, allowing for a scalable and cost-effective production process. Key features include:
- Biodegradable composition: Made from poly(lactic-co-glycolic acid) and chitosan.
- Gecko-inspired adhesion: Utilizes van der Waals interactions for strong adherence to epithelial tissues.
- High surface-area-to-volume ratio: Enhances drug loading capacity and retention.
- Sustained drug release: Encapsulated chemotherapeutic agents are released over time via an alginate hydrogel matrix.
Technology readiness level
This technology is at TRL 6, indicating a prototype has been demonstrated in relevant environments. Future validation will focus on expanding its application in biomedical fields and potentially other industries. The technology is patent-pending, and the development team is open to licensing or sub-licensing opportunities based on sponsor needs.
About University of Colorado, Boulder
The University of Colorado Boulder is a comprehensive public research university serving a large student body and a broad portfolio of scholarship. Corporate partners tap co-located federal research laboratories and shared-use core facilities, with collaborations supported by an on-campus research and technology park. Proximity to the Boulder–Denver innovation corridor and strong regional aerospace and photonics clusters provide access to suppliers, testbeds, and experienced talent. Research is supported by competitive federal funding, including awards from NSF, NIH, DOE, NASA, and DoD. A dedicated technology transfer office streamlines IP strategy, licensing, and startup formation, with incubator and accelerator programs connecting companies to faculty and student talent.
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