Customizable culture inserts for ECM remodeling and tissue regeneration
RESORB offers customizable electrospun cell culture inserts that enable in vitro assays to mimic complex tissue physiology. With biodegradable nanofiber sheets, these inserts allow the scaffold to be replaced with natural extracellular matrix, supporting advanced wound healing models.
Overview
RESORB introduces a groundbreaking solution for in vitro tissue modeling with customizable electrospun cell culture insert plates (CCIP). These inserts are designed to replicate the dynamic processes of extracellular matrix (ECM) remodeling and tissue regeneration. By utilizing biodegradable nanofiber sheets, the synthetic scaffold is gradually replaced by cell-generated ECM, providing a more accurate representation of cellular processes and interactions. This technology enables high-throughput screening of therapeutic compounds by simulating physiologically relevant tissue environments.
Technical specifications
Key features:
- Customizable nanofiber substrates with diameters ranging from 300-900 nm and pore sizes of less than 1-3 µm.
- Tunable degradation profiles from 2 to over 8 weeks, allowing adaptation to specific tissue regeneration timelines.
- Compatibility with high-throughput microscopic imaging and quantitative assays.
- Supports advanced coculture models for all stages of wound healing, using transepithelial electrical resistance (TEER) for quantification.
- Engineered with tunable chemistries such as PLA, PGA, and PCL to control scaffold properties effectively.
Technology readiness level
This technology is at TRL 5, indicating that it has been validated in relevant environments. Future efforts will focus on further validating the adaptability of RESORB membranes to specific biological environments and establishing advanced 3D coculture models to support multi-layered tissue growth and regenerative assays.
About Luna Labs
Luna Labs is a product development company based in Charlottesville, Virginia, that creates specialized solutions for the defense, industrial, and healthcare sectors. The company leverages a multidisciplinary approach combining materials science, biotechnology, and systems engineering to solve complex technical challenges. By repurposing advanced technologies—such as adapting sol-gel chemistry for corrosion prevention or mimicking viral structures for drug delivery—Luna Labs develops breakthrough innovations. Their diverse portfolio includes advanced protective coatings, real-time asset monitoring systems, medical simulation training tools, and drug delivery platforms designed to improve human performance and safeguard critical infrastructure.
These technologies address significant real-world problems, such as enhancing the durability of military and aerospace assets through non-chromate corrosion control and providing medical professionals with realistic training ecosystems for hemorrhage control. By partnering with government agencies, defense contractors, and leading industrial organizations, the company focuses on advancing research from initial discovery through to commercial-scale implementation. Their commitment to innovation is evidenced by the successful deployment of their technologies in high-stakes environments and their ongoing development of platforms intended to address complex conditions like PTSD and traumatic brain injury.
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