Cubosomal nanocarrier formulation for antifungal treatment
A novel cubosomal nanocarrier formulation designed to improve antifungal treatment efficacy while reducing toxicity. It encapsulates antifungal drugs, offering enhanced targeting and controlled release, leading to better therapeutic outcomes.
Overview
The cubosomal nanocarrier formulation represents a breakthrough in the treatment of fungal infections by reducing the toxicity associated with traditional antifungal drugs. By encapsulating drugs such as amphotericin B or azoles within cubosomes, this technology ensures selective delivery to infection sites. The unique structure of cubosomes, characterized by their high surface area-to-volume ratio, facilitates efficient drug loading and enhanced targeting through the EPR effect, ultimately improving treatment efficacy and minimizing side effects.
Technical specifications
Key features:
- Lipid-based cubosome nanoparticles: Provide a highly ordered lipid bilayer structure for effective encapsulation.
- Enhanced permeability and retention (EPR) effect: Enables selective targeting of fungal infections, ensuring higher drug concentration at the site.
- Reduced nephrotoxicity: Limits drug exposure to kidneys, decreasing the risk of kidney damage common with traditional antifungals.
- Controlled drug release: Allows sustained drug levels at the target site, improving therapeutic outcomes.
- High drug loading capacity: Maximizes the concentration of the antifungal agent delivered.
Technology readiness level
This technology is at TRL 3, having reached the experimental proof of concept stage. Ongoing research focuses on synthesizing drug-loaded cubosomes, conducting in vitro effectiveness studies, and validating efficacy in murine models to assess pharmacokinetics and pharmacodynamics.
About Amity University
Amity University is a private, multi-campus research university headquartered in Noida, operating at national scale with extensive laboratory infrastructure and a large talent pipeline. Industry engagement is organized through Corporate Resource/Industry Interaction Cells and advisory networks, and the Delhi–NCR location provides direct access to multinational headquarters, startups, and suppliers. For commercialization, the Amity Innovation Incubator and the Directorate of Innovation & Technology Transfer provide IP management, licensing support, and venture mentoring, while a DST‑supported Technology Enabling Centre connects faculty with national labs and companies. Research activity is backed by competitive funding from Indian agencies such as DST, DBT, ICMR and DRDO, alongside DSIR and UGC recognition.
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