Comparative method for hydrolysis monitoring in trialkoxysilanes
A comprehensive screening of spectroscopic and bulk-property methods to identify the most efficient approach for monitoring hydrolysis in organo-trialkoxysilane solutions, ensuring rapid, non-destructive, and scalable industrial applications.
Overview
This solution offers a comparative analysis of various spectroscopic and bulk-property methods to monitor hydrolysis in organo-trialkoxysilane solutions. It aims to identify the most effective technique by evaluating Raman, NIR/UV-Vis spectroscopy, fluorescence, DLS, and viscosity against a ¹D ²⁹Si NMR reference. The goal is to establish a validated, rapid, non-destructive, and scalable method that is suited for industrial deployment.
Technical specifications
Key features:
- Utilizes a range of spectroscopic methods including Raman, NIR/UV-Vis, and fluorescence
- Bulk-property methods such as DLS and viscosity are evaluated
- Quantitative ¹D ²⁹Si NMR serves as the calibration reference
- Multivariate models like PLS are employed for data correlation
- Portable devices for on-site analysis
Evaluation criteria include:
- Sensitivity and accuracy
- Speed of analysis
- Cost-effectiveness
- Robustness and reproducibility
Technology readiness level
Currently at TRL 4, the research involves extensive laboratory testing and initial validation phases. Future plans include further validation using independent samples and benchmarking each method against stringent performance criteria for industrial applicability.
About Drexel University
Drexel University is a comprehensive private research university in Philadelphia, recognized for an urban, industry‑embedded model anchored by a longstanding cooperative education program. Year‑round co‑ops create a ready talent pipeline and align sponsored research with real‑world needs. The campus sits within an innovation district with co‑located labs and incubators, enabling companies to collaborate on prototyping with faculty. Through the university’s medical college and clinical partners, industry teams can access clinical expertise and translational pathways. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, and DoD. A dedicated technology transfer office manages IP, licensing, corporate research agreements, and startup formation.
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