Capsultek: room-temperature encapsulation technology for bioactives
Bioinicia offers Capsultek, a disruptive electro-hydrodynamic encapsulation technology that enables one-step microencapsulation and drying of sensitive bioactives at room temperature. The technology protects functional ingredients from degradation and supports tailor-made formulations for food, nutraceutical, and pharmaceutical applications, validated at TRL9.
Overview
Functional ingredients such as antioxidants, omega-3 fatty acids, probiotics, and enzymes are highly sensitive to oxygen, light, and heat, and can degrade during processing and storage, losing their biological activity and commercial value. Bioinicia has developed Capsultek, a proprietary encapsulation technology based on electro-hydrodynamic atomization by pressured gas (EAPG), which enables one-step microencapsulation and drying of bioactives at room temperature. This gentle, single-step process preserves the functional integrity of sensitive compounds while producing high-quality encapsulates suitable for demanding industrial applications.
Technical specifications
Key features:
- Electro-hydrodynamic atomization by pressured gas (EAPG) uses a high electric field applied to a solution or suspension to generate ultrathin droplets and uniform, high-performance encapsulates
- One-step microencapsulation and drying at room temperature, eliminating thermal stress on heat-sensitive bioactives
- Scalable, non-aggressive process suitable for industrial production
- Supports multiple encapsulate formats:
- Water-soluble formats that extend bioactive shelf life
- Non-water-soluble formats that protect ingredients within water-based matrices
- Enteric formats enabling pH-controlled release
- Coaxial nozzle capability for generating more complex, multi-layered capsule structures
- Narrow particle size distribution for improved dispersion in target media
- Designed to withstand sterilization processes and maintain stability over extended shelf life
- Protected by patents granted in multiple jurisdictions, including the United States
Technology readiness level
Capsultek is at TRL9 and is commercially ready. The technology has been validated through the European Union Horizon 2020 SME Instrument project focused on unlocking the potential of thermo-sensitive bioactive ingredients. Proof-of-concept encapsulated products, including omega-3, probiotics, antioxidants, and enzymes, have been developed for food and beverage matrices at industrial scale. Bioinicia offers a structured project pathway covering formulation definition, proof-of-concept development, optimization, and validation, tailored to each customer's specific requirements.
About Bioinicia SL
Bioinicia SL is a Spanish biotechnology company and CSIC spin-off specializing in electro-hydrodynamic processing technologies, including electrospinning and electrospraying. The company designs and manufactures specialized industrial equipment, marketed under brands such as Fluidnatek, and offers contract development and manufacturing services. Its facilities include GMP-certified clean rooms with ISO 13485 certification, enabling the production of medical, pharmaceutical, and biomedical products. By leveraging its proprietary nanofiber and nanoparticle technologies, the company creates advanced materials, such as bioactive encapsulations, filtration media, and functional coatings.
These capabilities allow Bioinicia to support partners across the pharmaceutical, biomedical, cosmetic, and food industries throughout the entire product lifecycle, from initial research and development to industrial-scale manufacturing. The company addresses critical needs by providing innovative solutions for controlled drug delivery, tissue regeneration, and high-performance materials. Their expertise in scaling complex processes ensures that research concepts can be transitioned effectively into commercial products, making them a key partner for organizations requiring specialized, high-standard production environments.
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