Biotechnological platform for natural-grade lactone synthesis
Aminoverse B.V. offers a cutting-edge biotechnological platform for synthesizing natural-grade lactones from renewable fatty acids. This platform uses novel enzymes for high selectivity and scalability, enabling sustainable production of fragrance ingredients. The platform improves process efficiency by reducing side products and purification needs, offering a sustainable alternative to conventional synthetic routes.
Overview
Aminoverse B.V. introduces a biotechnological platform designed to synthesize natural-grade lactones from renewable fatty acid feedstocks. This innovative solution leverages a novel class of enzymes to convert fatty acids, such as decanoic acid, into lactones under mild aqueous conditions. The process efficiently produces hydroxy intermediates which subsequently form target lactones like γ- or δ-decalactone. This approach not only reduces side products and enhances selectivity but also supports scalable manufacturing from renewable resources, offering a sustainable alternative to traditional synthetic methods.
Technical specifications
Key features:
- Utilizes a novel enzyme class for enhanced selectivity and flexible manufacturing.
- Employs biocatalytic processes under mild conditions, reducing downstream purification needs.
- Capable of producing lactones like γ- and δ-decalactone with natural-grade quality.
- Enzymatic selectivity is optimized through machine learning algorithms.
- Compatible with various biotechnological production strategies, including enzyme catalysis and engineered microorganisms.
Technology readiness level
The platform is currently at Technology Readiness Level 4, indicating it has been validated in a lab environment. Future steps include increasing the TRL by scaling up production, broadening the application scope, and optimizing enzyme performance and reaction conditions. Partnership opportunities are available for co-development, licensing, supply purchase, and pilot trial engagements to support scalable downstream processing and lactone isolation.
About Aminoverse B.V.
Aminoverse is all about enzymes. Aminoverse B.V. is a Dutch biotechnology contract research organization (CRO) founded in 2020, specializing in enzyme research and development. The company provides a comprehensive suite of services that bridges the gap between laboratory-scale scientific discovery and industrial-scale application. By integrating a proprietary approach that combines wet-lab experiments, state-of-the-art in silico design, and AI-driven platforms, Aminoverse identifies and optimizes biocatalysts for specific chemical reactions, and application in products. This multidisciplinary strategy enables them to reduce development timelines, lower project risks, and address common bottlenecks in biocatalytic process engineering.
Operating as a customer-centric partner, Aminoverse functions as a temporary extension of a client's own R&D team, providing support for feasibility studies, robust assay development, and custom enzyme panel generation. Their business model emphasizes transparency and IP retention for clients, operating on a fee-for-service basis without royalties. Serving industries across pharmaceuticals, fine chemicals, nutraceuticals, flavor and fragrances, and feed, the company leverages its expertise to transform enzyme science into practical, cost-efficient, and sustainable industrial manufacturing processes and products. They also provide off-the-shelf enzyme kits for research applications, to facilitate the entrance into biocatalysis.
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