Bioactive compounds from brazilian fruits for obesity therapy
Exploring bioactive compounds from native Brazilian fruits to develop obesity therapies through in silico, in vitro, and clinical trials. Targeting obesity with nutraceutical and functional products derived from biodiversity.
Overview
This research focuses on utilizing the rich biodiversity of Brazilian fruits to combat obesity. By identifying bioactive compounds in fruits like jabuticaba, araticum, and passion fruit, the project aims to develop nutraceutical products that leverage antioxidant and anti-inflammatory properties to prevent obesity. This approach not only taps into the nutritional potential of these fruits but also contributes to public health improvement and environmental conservation.
Technical specifications
- Characterization of Nutritional Profile: Analysis of major bioactive compounds in Brazilian fruit by-products.
- Molecular Modeling: In silico screening to identify compounds affecting obesity signaling pathways.
- Bioaccessibility Evaluation: In vitro digestion studies to assess bioactive compound absorption and metabolism.
- Animal Models: Testing physiological effects on obesity through high-fat diet induced models.
- Clinical Trials: Randomized controlled trials to evaluate the impact of fruit by-products on obese volunteers, including biochemical and molecular analyses.
Technology readiness level
Currently at TRL 3, this research involves active R&D with experimental proof of concept established through initial in silico and in vitro studies, progressing towards further validation in animal models and clinical trials.
About Universidade Estadual de Campinas
Universidade Estadual de Campinas (Unicamp) is a comprehensive public research university in Campinas, São Paulo, recognized for high research intensity and strong graduate education. Industry engages through an on‑campus science and technology park with co‑located corporate R&D suites and shared core facilities. Clinical translation is enabled by an integrated teaching hospital and specialized centers, while proximity to the Campinas–São Paulo innovation corridor makes onsite collaboration and talent access straightforward. Research is supported by state and federal agencies such as FAPESP, CNPq, CAPES, and FINEP, alongside industry contracts. A dedicated technology transfer office manages IP, licensing, and startup formation, and offers clear pathways for NDAs, sponsored research, and scale‑up.
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