Propolis encapsulation in alginate gels for mastitis management in dairy cows
Develop a novel delivery system using propolis encapsulated in alginate gels to manage mastitis during the dry period in dairy cows, enhancing bioavailability and sustained antimicrobial release.
Overview
The proposed solution focuses on a novel delivery system for managing mastitis in dairy cows during the non-lactating phase. By encapsulating propolis in alginate composite gels, this method aims to enhance the bioavailability and sustained release of propolis's antimicrobial and anti-inflammatory properties. This innovative approach targets mastitis effectively during the critical dry period, thereby improving udder health and future milk production, benefiting farmers and animal welfare.
Technical specifications
- Propolis Extraction: High-quality propolis is extracted and characterized for its bioactive compounds.
- Alginate Gel Formulation: The propolis is encapsulated in alginate gels, ensuring controlled release and stability.
- In Vitro Testing: Laboratory studies assess the antimicrobial effectiveness against mastitis pathogens, establishing the minimum inhibitory concentration (MIC).
- In Vivo Trials: Conducted on non-lactating cows to evaluate safety and efficacy, with application via intramammary infusion.
Technology readiness level
Currently at Technology Readiness Level 2, this solution is undergoing early development stages with successful laboratory testing planned to lead into controlled in vivo trials. The process includes extraction, formulation, in vitro testing, and in vivo trials to ensure efficacy and compliance with veterinary and dairy regulations.
About Makabi Agritech
Makabi Agritech is a Croatian agritech company that has developed a proprietary 3-in-1 encapsulation technology for sustainable agricultural production. Utilizing green chemistry, the company creates biodegradable, bio-based microcapsules that combine plant protection, nutrient delivery, and the controlled release of bioactive components. This innovation is designed to replace traditional synthetic agrochemicals, with the goal of reducing environmental pollution, mitigating the impacts of climate change, and enhancing the biopotential and nutritional quality of food crops. The technology works by introducing microcapsules into the root zone or applying them to plant parts, where they dissolve to provide essential nutrients and protection precisely when needed. Founded in 2019 following research at the University of Zagreb, the company focuses on advancing sustainable farming practices through science-based innovations.
This technology is significant for the agricultural sector as it offers a scalable, eco-friendly alternative to conventional fertilizers and pesticides, potentially reducing agrochemical usage by up to 30 percent. By improving soil health and promoting the production of functional, safer food for human consumption, Makabi Agritech addresses critical global sustainability goals, including zero hunger and responsible consumption. The company actively engages in research and development collaborations, participates in international innovation challenges, and has received recognition and funding for its contributions to sustainable chemistry. Its solutions have been tested on various crops, including strawberries, tomatoes, and tobacco, in both field and greenhouse environments.
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