Cyclodextrin-stabilized creatine powders via electrostatic spray drying
Innovative cyclodextrin-stabilized creatine powders enhance solubility and stability, utilizing electrostatic spray drying to create pH-sensitive microcapsules for improved bioavailability. Ideal for integration in food and beverage applications.
Overview
This solution utilizes cyclodextrin-stabilized creatine powders produced through electrostatic spray drying, aimed at enhancing the solubility and stability of creatine in food and beverage applications. The inclusion complexes formed with GRAS cyclodextrins prevent intramolecular cyclization, boosting solubility, while the glass-forming matrix of maltodextrin and trehalose immobilizes the complex, offering protection during high-temperature processing. The innovative use of electrostatic spray drying creates pH-sensitive microcapsules that ensure bioavailability by dissolving in gastric conditions.
Technical specifications
- Cyclodextrin inclusion complex: Enhances solubility, blocks cyclization.
- Glass-forming matrix: Maltodextrin/trehalose provides thermal stability.
- Electrostatic spray drying: Low-temperature, inert-gas process for stable powders.
- Alginate/pectin coating: Ensures stability in aqueous environments, dissolves at gastric pH.
- Solubility: Achieves ≥15 g·L⁻¹ effective solubility.
- Shelf stability: Maintains stability for >9–12 months post-thermal processing.
- Neutral sensory impact: Maintains taste and texture in final product.
Technology readiness level
This technology is currently at TRL 4, with initial formulation and bench proof completed. Future phases include process optimization, pilot-scale production, and regulatory compliance documentation to advance to pilot-scale production and industrial integration.
About Catholic University of Leuven (KU Leuven)
KU Leuven is a large comprehensive public research university in Leuven, Belgium, anchored by a major academic medical center and a broad multidisciplinary profile. Industry engages through co-located facilities and shared labs, including access to advanced cleanrooms and prototyping via imec’s Leuven campus. Integration with UZ Leuven supports clinical partnerships and data-rich trials, while research and technology parks around the city connect companies with faculty and student talent. Research is backed by competitive European and Belgian funding, including the European Commission and the Research Foundation – Flanders (FWO). KU Leuven Research & Development manages IP, licensing, and spin-off formation, offering standardized agreements and dedicated partnership managers.
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