Bio-based ion-exchange platform for pharma-grade protein purification at food-scale economics

BioResin, a next-generation, sustainable molecular separation technology designed to transform downstream processing in food, biotech, and pharma. BioResin is a bio-based separation medium produced from agricultural byporducts, enabling high-performance purification of proteins, enzymes, and other target molecules. Traditional molecular separation relies on synthetic resins and complex chromatography systems. These solutions are costly (often >$1,000/L), require significant capital investment, and have limited production capacity due to chemical complexity and supply constraints. At the same time, many manufacturers face critical bottlenecks in downstream processing, especially in precision fermentation, alt. proteins, and high-value ingredient production, where purification represents up to 70% of production cost. BioResin addresses these pain points: it is biodegradable, 10–20x cheaper (up to $100L), compatible with existing equipment and scalable.

Medium Well enhances natural separation properties into a functional separation medium with charge and size-based binding properties. The material can be packed into standard columns or tanks and integrated seamlessly into existing downstream processing systems without major equipment changes.

BioResin demonstrated promising performance in early validation projects with precision fermentation partners and ingredient manufacturers. Laboratory and pilot tests showed competitive yields and selectivity compared to high-end commercial resins. POC validated performance over filtration systems, especially where filtration leads to product loss or limited purity.

BioResin represents a cost-effective, sustainable purification platform that not only mitigates current DSP challenges but also unlocks new opportunities for strategic partners to compete with legacy technologies and differentiate their offerings in a growing bio-based economy.