Rajarajan Amirthalingam Thandavarayan's profile

Rajarajan Amirthalingam Thandavarayan

Principal Investigator

Houston Methodist

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8 months ago

Cardiometabolic biology, RNA processing, inflammation therapeutics

About

Studies cardiometabolic disease mechanisms across inflammation, oxidative/ER stress and fibrosis. Focus on RNA regulation (microRNAs, alternative polyadenylation) in heart failure and diabetes. Tests modulators and nano‑delivery toward translation.

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Houston Methodist

Aav9-mediated RNA interference targeting CSTF64 for heart failure therapy

This innovative therapy utilizes AAV9-mediated RNA interference to inhibit CSTF64, aiming to reduce cardiac fibrosis and improve heart function. Preliminary studies suggest CSTF64 upregulation exacerbates fibrosis, while...

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Rajarajan Amirthalingam Thandavarayan

Principal Investigator

Houston Methodist

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Houston Methodist

Principal Investigator

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Last updated Jan 2026