JH
Jack Vanden Heuvel
Principal Investigator
INDIGO Biosciences, Inc.
I'm working on
7 months ago
Microbiome–bile acid signaling, metabolic pharmacology, environmental toxicology
About
Studies how microbiome-derived bile acids regulate nuclear receptors and metabolism. Uses in vivo models, cell systems and metabolomics to identify and test interventions, and to assess environmental exposures via bioassay‑guided detection and remediation.
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INDIGO Biosciences, Inc.

Fluorescent cell-based assay system for SGLT1 and GLUT5 transporter screening

A cell-based fluorescent assay platform for rapid screening of compounds that activate or inhibit SGLT1 and GLUT5 sugar transporters. Replaces radioactive isotope methods with safe, cost-effective fluorescent glucose and...

Consulting serviceCompany
INDIGO Biosciences, Inc.

All-natural synergistic formulation to combat fusarium crop diseases

Research program developing an optimized, all-natural biofungicide combining bioactive ingredients from essential oils, lactic acid bacteria, and insect-derived peptides to fight fusarium diseases in crops more effective...

TechnologyConceptualCompany
JH
Penn State University

Tiered high-throughput screening platform for hair follicle biology

A scalable, tiered screening platform integrating mechanistic assays and follicular cell models to identify modulators of hair follicle biology. Offers pathway-resolved insights and improved translatability for efficient...

TechnologyIn developmentUniversity
JH
Penn State University

Topical combination therapy targeting peripheral neuropathy

A topical ointment designed for peripheral neuropathy, combining quercetin, ascorbyl palmitate, and vitamin D3 to alleviate pain, promote nerve repair, and offer an opioid-free alternative. Suitable for diabetic, chemoth...

TechnologyIn developmentUniversity
JH
Penn State University

Modulation of bile acid receptors FXR and TGR5 for enhanced GLP-1 release

This research explores inhibiting FXR to enhance GLP-1 secretion via TGR5 activation, improving metabolic parameters in obesity treatment. Potential synergy with GLP-1 receptor agonists offers a novel combinatory approac...

TechnologyIn developmentUniversity
JH
Penn State University

Estrogen receptor modulators for hair follicle growth regulation

Explore natural ingredients that modulate hair follicle growth through selective estrogen receptor modulation. This innovative approach uses high-throughput assays to assess receptor interactions and steroidogenesis, pro...

TechnologyIn developmentUniversity
JH
Jack Vanden Heuvel
Principal Investigator
INDIGO Biosciences, Inc.
Work experience
INDIGO Biosciences, Inc.
Founder/CSO
2005 - Present
Professor of Molecular Toxicology
1997 - Present
Top industry applications
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Results may appear later and can be imperfect.
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Not enough data yet.
Results may appear later and can be imperfect.
Last updated Mar 2026
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