Galia Blum's profile

Galia Blum

Principal Investigator

Hebrew University of Jerusalem

I'm working on

4 years ago

Developing protease imaging probes and their in vivo applications

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My lab combines chemistry and biochemical methodologies to generate protease probes suitable for studying proteases in vitro, in tissue cultures, in live animals and even in human samples. These probes enable studying the involvement of proteases in diseases and non-invasive imaging applications.

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Hebrew University of Jerusalem

Pet-labeled cathepsin activity-based probes for studying lysosomal storage disorder therapies

Novel small-molecule probes that covalently bind lysosomal cathepsin proteases for PET imaging of lysosomes in lysosomal storage disorder (LSD) models. Built on a potent dipeptide electrophile core (IC50 < 1µM), these pr...

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Galia Blum

Principal Investigator

Hebrew University of Jerusalem

Work experience

Hebrew University of Jerusalem

Principal Investigator

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Last updated Jul 2022